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KMID : 1189420220350030066
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2022 Volume.35 No. 3 p.66 ~ p.94
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A Review on the of External Ointment Treatment for Diabetic Foot Ulcer
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Jeong Mi-Rae
Heo Eun-Na
Kim Chul-Yun
Kwon Kang
Seo Hyung-Sik
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Abstract
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Objectives : Diabetic Foot Ulcer(DFU) is one of the common complications of diabetes. DFU is difficult to treat compared to other chronic wounds and clinically effective treatments are limited. The purpose of this study is to review the of external ointment treatment for DFU.
Methods : 8 databases such as PubMed, EMBASE, CENTRAL, CNKI, NDSL, RISS, KISS, OASIS including English, Korean and Chinese were searched by structured search strategies that consist of terms as ‘diabetic foot’, ‘diabetic foot ulcer(DFU)’ and ‘randomized’ from January 2001 to January 2021. All randomized controlled trials(RCTs) involving treatment group as external ointment or in combination with conventional treatment were included.
Results: A total of 20 RCTs was identified and analyzed. In treatment group, ointment was applied based on conventional treatment. A total of 16 different ointments were used, and the frequency of use was highest in the order of Heat-clearing drug, Blood-activating and stasis-dispelling drug, Tonifying and Replenishing drug and Orifice-opening drug. The most used herbs were in the order of Coptis chinensis Franch., Phellodendron chinense Schneid., Borneolum syntheticum., Angelica sinensis(Oliv.) Diels. In treatment group, a clinically effective effect was obtained compared to the contrast group.
Conclusions : The result of this study suggest that external ointment treatment based on conventional treatment can be applied to DFU.
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KEYWORD
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Diabetic foot ulcer, External ointment, DFU, Diabetes
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